Israel carried out a missile strike targeting an air defense unit in southern Syria, causing material damage, state-run SANA news agency quoted a military statement as saying Friday.

The warplanes were seen around the time loud noises and drones were reported near a major Iranian air base and nuclear site early Friday. That area of Syria is directly west of Isfahan, some 930 miles away, and east of Israel. Iran fired air defense batteries early Friday after reports of explosions near a major airbase and nuclear site where drones were spotted.

U.S. Secretary of State Antony Blinken didn’t comment about the latest Middle East developments as he arrived for the final session Friday morning of a Group of Seven foreign ministers’ meeting in Capri, Italy.

Israel has vowed to respond to Iran’s unprecedented weekend attack, leaving the region bracing for further escalation after months of fighting in Gaza. Allies have urged Israel to hold back on any response to the attack that could spiral. The United States and Britain announced Thursday that they were imposing a new round of sanctions on Iran.

Regional tensions have increased since the start of the latest Israel-Hamas war on Oct. 7, when Hamas and Islamic Jihad — two militant groups backed by Iran — carried out a cross-border attack that killed 1,200 people in Israel and kidnapped 250 others. Israel responded with an offensive in Gaza that has caused widespread devastation and killed more than 33,900 people, according to local health officials.