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Navy, CDC hope to learn about coronavirus from the USS Theodore Roosevelt outbreak

U.S. Navy Airman Andrue Barraza, from San Antonio, departs the aircraft carrier USS Theodore Roosevelt on for quarantine in Guam after completing essential watch-standing duties April 25, 2020.

CHRIS LIAGHAT/U.S. NAVY

By ANDREW DYER | The San Diego Union-Tribune | Published: April 26, 2020

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(Tribune News Service) — An investigation by the Navy and the Centers for Disease Control and Prevention into the outbreak of the novel coronavirus aboard the San Diego-based aircraft carrier USS Theodore Roosevelt could yield data valuable not just to the military, but also to the greater scientific community in the race to understand the virus better, the Navy says.

The Roosevelt has been tied up in Guam for the past month as the virus spread throughout its crew.

More than 17% of the ship’s approximately 4,845 sailors have tested positive for the virus — 856 sailors. There are still a handful of results outstanding, the Navy said Friday.

Four sailors are in the hospital at Naval Base Guam. Another, Chief Aviation Ordnanceman Charles Thacker, 41, died from the virus last week.

Since Monday, the Navy has been surveying members of the crew as part of its investigation. The Navy and the CDC said previously they hoped to survey 1,000 sailors, obtaining saliva and blood tests.

Cmdr. Denver Applehans, a spokesman for the Navy Bureau of Medicine and Surgery, said in an email Friday the service asked 1,400 sailors to participate. The Navy fell well short of that goal.

“We are very thankful to the roughly 400 crewmembers of the USS Theodore Roosevelt who provided specimens for this outbreak investigation,” Applehans wrote in an email. “It’s worth noting that the USS Theodore Roosevelt’s crew has been impacted by this virus harder than any other military unit and there are many competing demands on the crew to get the ship clean and ready to return to sea. We can’t overemphasize our appreciation for those who did volunteer.”

The goal of the investigation, officials said, is to understand the behavior of the virus better and to apply those lessons to other Navy ships and military units.

The outbreak on the Roosevelt presents an opportunity to understand how the disease spreads in a relatively controlled environment, said Shane Crotty, a virologist and professor in the Vaccine Discovery Division at La Jolla Institute for Immunology in San Diego.

“It’s really an outstanding opportunity to learn more,” Crotty said. “That’s the type of scenario — a controlled environment, far fewer variables — it’s the kind of situation epidemiologists love because of the minimization of variables. For my side, we’re very interested in understanding viral immunology — the response (to the virus). In particular, how that would help vaccine development.”

The development of an effective vaccine for the virus is seen by many as key to getting life around the world back to normal. The La Jolla Institute for Immunology is leading an international effort to collect antibody samples, which are key in vaccine development.

Blood samples from the Roosevelt investigation will be tested at the CDC’s laboratory in Atlanta using the agency’s new serology test, which can identify antibodies and can tell researchers whether a person has been exposed to the virus even if they are showing no symptoms.

On the Roosevelt, Applehans said, the rate at which asymptomatic sailors test positive for the virus is on the high end of what the CDC says can be expected in the general population.

“Approximately 50% of the sailors who tested positive so far on the (Theodore Roosevelt) have not shown symptoms of COVID-19,” Applehans said.

“The CDC has said that roughly 25% of COVID-19 infections are asymptomatic across all age groups. Given that the Sailors are generally younger and healthier than the general population across all age groups, 50% or even slightly above may be appropriate or expected.”

Applehans said the Navy expects to gain more clarity on asymptomatic carriers and virus transmission through its ongoing outbreak investigations.

Among the questions Crotty has is whether asymptomatic people who test positive for the virus develop an immune response — something the CDC’s antibody test might reveal.

“From my area in expertise, for us thinking about vaccine development and immunity, one missing piece is: Do asymptomatic cases develop immune responses or not?” Crotty said. “The blood tests on the sailors should reveal that pretty quickly.”

That immune response — one that effectively fights off the virus — would tell researchers what an effective response looks like.

“Right now, there are over 80 different vaccine candidates,” Crotty said. “Once you have information in hand on what a good immune response looks like, it can help point out what vaccine strategy works. That’s really valuable information — they’re going to have very high-quality data about true asymptomatic cases.”

On the Roosevelt, and unlike anywhere else with an outbreak, 100% of those potentially exposed to the virus have been tested. Although not all of the crew participated in the Navy and CDC’s investigation, and the goal is not specifically for vaccine development, the Navy is hopeful its results are useful.

“What this outbreak investigation will provide is some basic information about exposure to the virus aboard the ship and the development of antibodies from that exposure,” Applehans said. “We hope it is useful in providing some additional information on how this virus is transmitted.”

In addition to the blood and saliva samples taken from sailors, officials also had volunteers fill out surveys to track their locations aboard the ship.

The Navy’s surgeon general, Rear Adm. Bruce Gillingham, said last week one of the goals of the investigation is to determine how much the virus spread without having sailors show symptoms.

“Because of the presymptomatic transmission, we believe that it probably passed through the ship quite freely and was initially unrecognized,” Gillingham said.

The Roosevelt pulled into Guam on March 28 as the virus spread out of control among its crew. It is the largest outbreak of the virus in the U.S. military.

The first two cases of the virus were found among two members of the ship’s air wing, a Navy official told the Union-Tribune. However, because the two cases came to light 15 days after a port visit to Vietnam, Gillinghan could not say how the virus got aboard.

He said that is not the intent of the investigation.

“The intent of investigation is not to get to the source; it’s to better understand the behavior of the virus going forward,” he said.

Other factors the Navy is learning about the virus came to light this week, as the service reported some quarantined sailors tested positive for the virus more than 14 days after testing negative.

Experts point to the virus’ long incubation period as being one of the key factors making its spread difficult to slow.

While the Navy’s interests in the investigation lean more toward getting back to sea and conducting operations, Applehans said the CDC will share its data with researchers on the civilian side as well.

“Our partners at CDC will share that information with the broader scientific community as is useful,” Applehans said. “We won’t know for sure until the specimens are processed and the data analyzed, but everything we can learn about this new virus is useful and contributes to the larger body of scientific knowledge that will increase our understanding of how we can prevent, treat, and mitigate COVID-19.”

The Navy expected its survey of the crew to finish Friday. Results from the CDC are not due for at least one month.

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